New advances in diagnosis and treatment of nano drug delivery systems across the blood-brain barrier

The blood-brain barrier (BBB) is a multicellular neurovascular unit that serves as highly impermeable cellular to regulate brain homeostasis, protect the central nervous system, and respond different physiological pathological states. Recently, new drugs have been discovered treat neuropathology. However, because BBB blocks delivery of system (CNS), it still difficult translate treatment CNS diseases into clinical results. Therefore, overcoming realizing efficient therapeutic great significance for diagnosis various neurological such Alzheimer’s disease, Parkinson’s disease glioblastoma. Nano drug (NDDS) has characteristics high biocompatibility, load, improving pharmacokinetic behavior in vivo, achieving targeted delivery, controlled release, etc. field trans-BBB It broad application prospect diseases. This paper reviews latest research on NDDS crossing at home abroad, providing ideas